A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses

被引：640

作者：

Hall, N

Karras, M

Raine, JD

Carlton, JM

Kooij, TWA

Berriman, M

Florens, L

Janssen, CS

Pain, A

Christophides, GK

James, K

Rutherford, K

Harris, B

Harris, D

Churcher, C

Quail, MA

Ormond, D

Doggett, J

Trueman, HE

Mendoza, J

Bidwell, SL

Rajandream, MA

Carucci, DJ

Yates, JR

Kafatos, FC

Janse, CJ

Barrell, B

Turner, CMR

Waters, AP

Sinden, RE

机构：

[1] Wellcome Trust Sanger Inst, Pathogen Sequencing Unit, Cambridge CB10 1SA, England

[2] Leiden Univ, Med Ctr, Dept Parasitol, Malaria Grp, NL-2300 RA Leiden, Netherlands

[3] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, Immunol & Infect Sect, London SW7 2AZ, England

[4] Inst Genom Res, Rockville, MD 20850 USA

[5] Univ Florida, Coll Vet Med, Dept Pathobiol, Gainesville, FL 32608 USA

[6] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

[7] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[8] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

[9] European Mol Biol Lab, D-69117 Heidelberg, Germany

[10] Naval Med Res Ctr, Malaria Program IDD, Silver Spring, MD 20910 USA

来源：

SCIENCE | 2005年 / 307卷 / 5706期

关键词：

D O I：

10.1126/science.1103717

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites' life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3' untranslated region motif is implicated in this process.

引用

页码：82 / 86

页数：5

共 27 条

[1] Methods and statistics for combining motif match scores [J].