The recognition and cleavage of RNA in the antisense oligo-RNA hybrid duplexes by RNase H

被引：4

作者：

Amirkhanov, NV ^{[1
]}

Zamaratski, E ^{[1
]}

Chattopadhyaya, J ^{[1
]}

机构：

[1] Univ Uppsala, Ctr Biomed, Dept Bioorgan Chem, S-75123 Uppsala, Sweden

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(00)01997-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The different extent of the target RNA cleavage at t(99.9%) by RNase H in the AON-RNA duplexes, at the RNA saturation condition by antisense oligo, is due to different recognition and catalytic properties of RNase H toward the hybrids owing to different substituents at the 3'-end of the AONs, not owing to the different thermodynamic stabilities of the antisense oligonucleotide (AON)-RNA duplexes. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：489 / 491

页数：3

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