Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial

被引:87
作者
Keranis, E. [2 ]
Makris, D. [1 ,2 ]
Rodopoulou, P. [2 ]
Martinou, H. [2 ]
Papamakarios, G. [2 ]
Daniil, Z. [2 ]
Zintzaras, E. [3 ,4 ]
Gourgoulianis, K. I. [2 ]
机构
[1] Univ Thessaly, Sch Med, Dept Crit Care Med, Larisa 4110, Thessaly, Greece
[2] Univ Thessaly, Sch Med, Dept Resp Med, Larisa 4110, Thessaly, Greece
[3] Univ Thessaly, Sch Med, Dept Biomath, Larisa 4110, Thessaly, Greece
[4] Tufts Univ, Sch Med, Ctr Clin Evidence Synth, Inst Clin Res & Hlth Policy Studies,Tufts Med Ctr, Boston, MA 02111 USA
关键词
Chronic obstructive pulmonary disease; diet antioxidants; epidemiology; OBSTRUCTIVE PULMONARY-DISEASE; LUNG-FUNCTION; VITAMIN-C; RESPIRATORY SYMPTOMS; DECLINE; FRUITS;
D O I
10.1183/09031936.00113809
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Chronic obstructive pulmonary disease (COPD) is characterised by increased oxidative stress. Dietary factors, such as ample consumption of foods rich in antioxidants, such as fruit and vegetables, might have beneficial effects in COPD patients. The association between dietary shift to foods rich in antioxidants and lung function in COPD was investigated in a 3-yr prospective study. A total of 120 COPD patients were randomised to follow either a diet based on increased consumption of fresh fruit and vegetables (intervention group (IG)) or a free diet (control group (CG)). The mean consumption of foods containing antioxidants was higher in the IG than in the CG throughout the study period (p < 0.05). The relationship between consumption of foods rich in antioxidants and percentage predicted forced expiratory volume in 1 s was assessed using a general linear model for repeated measures; the two groups overall were different in time (p=0.03), with the IG showing a better outcome. In investigating the effect of several confounders (sex, age, smoking status, comorbid conditions and exacerbation) of group response over time, nonsignificant interactions were found between confounders, group and time. These findings suggest that a dietary shift to higher-antioxidant food intake may be associated with improvement in lung function, and, in this respect, dietary interventions might be considered in COPD management.
引用
收藏
页码:774 / 780
页数:7
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