The relation between glutamine and the immunodepression observed in exercise

被引:33
作者
Castell, LM [1 ]
Newsholme, EA [1 ]
机构
[1] Univ Oxford, Dept Biochem, Oxford, England
关键词
amino acids; glutamine; exhaustive exercise; immunodepression;
D O I
10.1007/s007260170065
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutamine is the most abundant amino acid in the body. It is an important fuel for some key cells of the immune system. Both the plasma concentration of glutamine and the functional ability of immune cells in the blood are decreased after prolonged, exhaustive exercise. Glutamine feeding has had beneficial effects in clinical situations, and the provision of glutamine after intensive exercise has decreased the incidence of infections, particularly of upper respiratory tract infections. However, the precise effect of glutamine on immunodepression in this situation is not yet established.
引用
收藏
页码:49 / 61
页数:13
相关论文
共 62 条
[31]   INFLUENCE OF A 36-H FAST FOLLOWED BY REFEEDING WITH GLUCOSE, GLYCEROL OR PLACEBO ON METABOLISM AND PERFORMANCE DURING PROLONGED EXERCISE IN MAN [J].
MAUGHAN, RJ ;
GLEESON, M .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 1988, 57 (05) :570-576
[32]   THE LEUKOCYTOSIS OF EXERCISE - A REVIEW AND MODEL [J].
MCCARTHY, DA ;
DALE, MM .
SPORTS MEDICINE, 1988, 6 (06) :333-363
[33]  
NASH HL, 1986, PHYSICIAN SPORTSMED, V14, P251
[34]  
NESHOLME EA, 2000, IN PRESS BIOCH MED S
[35]  
Newsholme E A, 1987, Biochem Soc Symp, V54, P145
[36]   GLUTAMINE-METABOLISM IN LYMPHOCYTES - ITS BIOCHEMICAL, PHYSIOLOGICAL AND CLINICAL IMPORTANCE [J].
NEWSHOLME, EA ;
CRABTREE, B ;
ARDAWI, MSM .
QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1985, 70 (04) :473-489
[37]  
NEWSHOLME EA, 1990, JPEN S, V14, P63
[38]  
NEWSHOLME EA, 1995, KEEP RUNNING
[39]  
NIEMAN D, 1990, J SPORTS MED PHYS FI, V30, P289
[40]   EXERCISE, UPPER RESPIRATORY-TRACT INFECTION, AND THE IMMUNE-SYSTEM [J].
NIEMAN, DC .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1994, 26 (02) :128-139