Molluscicidal and trypanocidal activities of lapachol derivatives

被引：62

作者：

dos Santos, AF

Ferraz, PAL

de Abreu, FC

Chiari, E

Goulart, MOF

Sant'Ana, AEG

机构：

[1] Univ Fed Alagoas, CCEN, Dept Quim, Maceio, Alagoas, Brazil

[2] Univ Fed Pernambuco, Dept Quim Fundamental, Recife, PE, Brazil

[3] Univ Fed Minas Gerais, ICB, Dept Parasitol, Belo Horizonte, MG, Brazil

来源：

PLANTA MEDICA | 2001年 / 67卷 / 01期

关键词：

D O I：

10.1055/s-2001-10877

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The activity of the potassium salt of lapachol against the snail Biomphalaria glabrata and its egg masses was tested. The obtained IC,, values (2.70 ppm and 1.43 ppm, respectively) are indicative of a strong activity. Lapachol derivatives were also assayed against infective trypomastigote blood forms of T.cruzi and the triacetoxy derivative of reduced lapachol showed relevant trypanocidal activity, killing 95.7 % of the parasites at the concentration of 42 mug/mL.

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收藏

页码：92 / 93

页数：2

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