Antiatherogenic effects of the antioxidant BO-653 in three different animal models

被引:79
作者
Cynshi, O
Kawabe, Y
Suzuki, T
Takashima, Y
Kaise, H
Nakamura, M
Ohba, Y
Kato, Y
Tamura, K
Hayasaka, A
Higashida, A
Sakaguchi, H
Takeya, M
Takahashi, K
Inoue, K
Noguchi, N
Niki, E
Kodama, T
机构
[1] Chugai Pharmaceut Co Ltd, Fujigotemba Res Labs, Gotemba, Shizuoka 412, Japan
[2] Kumamoto Univ, Sch Med, Dept Biochem 2, Kumamoto 860, Japan
[3] Juntendo Univ, Sch Med, Bunkyo Ku, Tokyo 113, Japan
[4] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 153, Japan
关键词
D O I
10.1073/pnas.95.17.10123
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Antioxidants have been proposed to have antiatherogenic potential by their inhibition of low density lipoprotein (LDL) oxidation. Here, we report an antioxidant, BO-653 (2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran), designed to exhibit antioxidative potency comparable to that of a-tocopherol, but yet possess a high degree of lipophilicity comparable to that of probucol. BO-653 exhibits a high affinity for LDL and is well distributed in aortic vessels in vivo. In atherosclerosis models of rabbits and mice, BO-653 has been shown to be able to suppress the formation of atherosclerotic lesions without untoward side effects. Specifically, there was no reduction of high density lipoprotein levels. This antioxidant provides additional evidence in support of the oxidized-LDL hypothesis, and itself is a promising candidate antioxidant for clinical use.
引用
收藏
页码:10123 / 10128
页数:6
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