The I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant

被引：32

作者：

Simon, Philippe ^{[1
]}

Holder, Benjamin P. ^{[2
]}

Bouhy, Xavier ^{[1
]}

Abed, Yacine ^{[1
]}

Beauchemin, Catherine A. A. ^{[2
]}

Boivin, Guy ^{[1
]}

机构：

[1] Univ Laval, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada

[2] Ryerson Univ, Dept Phys, Toronto, ON M5B 2K3, Canada

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 02期

基金：

加拿大健康研究院;

关键词：

INHIBITOR; INFECTION;

D O I：

10.1128/JCM.01732-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V NA mutation.

引用

页码：715 / 717

页数：3

共 21 条

[1] Treatment of respiratory virus infections [J].

Abed, Yacine ;

Boivin, Guy .

ANTIVIRAL RESEARCH, 2006, 70 (02) :1-16

[2] Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an Immunocompromised child [J].

Baz, Mariana ;

Abed, Yacine ;

McDonald, Jane ;

Boivin, Guy .

CLINICAL INFECTIOUS DISEASES, 2006, 43 (12) :1555-1561

[3] Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses [J].

Baz, Mariana ;

Abed, Yacine ;

Simon, Philippe ;

Hamelin, Marie-Eve ;

Boivin, Guy .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (05) :740-745

[4] Oseltamivir-Resistant Influenza A Viruses Are Transmitted Efficiently among Guinea Pigs by Direct Contact but Not by Aerosol [J].

Bouvier, Nicole M. ;

Lowen, Anice C. ;

Palese, Peter .

JOURNAL OF VIROLOGY, 2008, 82 (20) :10052-10058

[5]

*CDCP, 2010, FLUVIEW 2008 2009 IN

[6]

*CDCP, 2010, FLUVIEW 2009 2010 IN

[7] Enhanced expression of an α2,6-linked sialic acid on MDCK cells improves isolation of human influenza viruses and evaluation of their sensitivity to a neuraminidase inhibitor [J].

Hatakeyama, S ;

Sakai-Tagawa, Y ;

Kiso, M ;

Goto, H ;

Kawakami, C ;

Mitamura, K ;

Sugaya, N ;

Suzuki, Y ;

Kawaoka, Y .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :4139-4146

[8]

Hayden Frederick G., 2002, P891

[9] Influenza viruses resistant to the antiviral drug oseltamivir: Transmission studies in ferrets [J].

Herlocher, ML ;

Truscon, R ;

Elias, S ;

Yen, HL ;

Roberts, NA ;

Ohmit, SE ;

Monto, AS .

JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (09) :1627-1630

[10] In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses [J].

Hurt, Aeron C. ;

Holien, Jessica K. ;

Barr, Ian G. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (10) :4433-4440

← 1 2 3 →