The I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant

被引：32

作者：

Simon, Philippe ^{[1
]}

Holder, Benjamin P. ^{[2
]}

Bouhy, Xavier ^{[1
]}

Abed, Yacine ^{[1
]}

Beauchemin, Catherine A. A. ^{[2
]}

Boivin, Guy ^{[1
]}

机构：

[1] Univ Laval, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada

[2] Ryerson Univ, Dept Phys, Toronto, ON M5B 2K3, Canada

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 02期

基金：

加拿大健康研究院;

关键词：

INHIBITOR; INFECTION;

D O I：

10.1128/JCM.01732-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V NA mutation.

引用

页码：715 / 717

页数：3