The neural stem cell niche

被引：111

作者：

Conover, Joanne C. ^{[1
,2
]}

Notti, Ryan Q. ^{[2
]}

机构：

[1] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06250 USA

[2] Univ Connecticut, Ctr Regenerat Biol, Storrs, CT 06250 USA

来源：

CELL AND TISSUE RESEARCH | 2008年 / 331卷 / 01期

关键词：

neural stem cell niche; neurogenesis; neural stem cell; neural progenitors; aging;

D O I：

10.1007/s00441-007-0503-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The neural stem cell niche defines a zone in which stem cells are retained after embryonic development for the production of new cells of the nervous system. This continual supply of new neurons and glia then provides the postnatal and adult brain with an added capacity for cellular plasticity, albeit one that is restricted to a few specific zones within the brain. Critical to the maintenance of the stem cell niche are microenvironmental cues and cell-cell interactions that act to balance stem cell quiescence with proliferation and to direct neurogenesis versus gliogenesis lineage decisions. Ultimately, based on the location of the niche, stem cells of the adult brain support regeneration in the dentate gyrus of the hippocampus and the olfactory bulb through neuron replacement. Here, we provide a summary of the current understanding of the organization and control mechanisms of the neural stem cell niche.

引用

页码：211 / 224

页数：14

共 159 条

[31]

Chiasson BJ, 1999, J NEUROSCI, V19, P4462

[32] Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone [J].

Conover, JC ;

Doetsch, F ;

Garcia-Verdugo, JM ;

Gale, NW ;

Yancopoulos, GD ;

Alvarez-Buylla, A .

NATURE NEUROSCIENCE, 2000, 3 (11) :1091-1097

[33] The subventricular zone: new molecular and cellular developments [J].

Conover, JC ;

Allen, RL .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (12) :2128-2135

[34] Telencephalic cells take a tangent: non-radial migration in the mammalian forebrain [J].

Corbin, JG ;

Nery, S ;

Fishell, G .

NATURE NEUROSCIENCE, 2001, 4 (Suppl 11) :1177-1182

[35] Dopamine D3 receptor stimulation promotes the proliferation of cells derived from the post-natal subventricular zone [J].

Coronas, V ;

Bantubungi, K ;

Fombonne, J ;

Krantic, S ;

Schiffmann, SN ;

Roger, M .

JOURNAL OF NEUROCHEMISTRY, 2004, 91 (06) :1292-1301

[36] Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension [J].

Curtis, Maurice A. ;

Kam, Monica ;

Nannmark, Ulf ;

Anderson, Michelle F. ;

Axell, Mathilda Zetterstrom ;

Wikkelso, Carsten ;

Holtas, Stig ;

van Roon-Mom, Willeke M. C. ;

Bjork-Eriksson, Thomas ;

Nordborg, Claes ;

Frisen, Jonas ;

Dragunow, Michael ;

Faull, Richard L. M. ;

Eriksson, Peter S. .

SCIENCE, 2007, 315 (5816) :1243-1249

[37] Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells [J].

Di Giorgi-Gerevini, V ;

Melchiorri, D ;

Battaglia, G ;

Ricci-Vitiani, L ;

Ciceroni, C ;

Busceti, CL ;

Biagioni, F ;

Iacovelli, L ;

Canudas, AM ;

Parati, E ;

De Maria, R ;

Nicoletti, F .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (08) :1124-1133

[38] Regeneration of a germinal layer in the adult mammalian brain [J].

Doetsch, F ;

García-Verdugo, JM ;

Alvarez-Buylla, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11619-11624

[39] Subventricular zone astrocytes are neural stem cells in the adult mammalian brain [J].

Doetsch, F ;

Caillé, I ;

Lim, DA ;

García-Verdugo, JM ;

Alvarez-Buylla, A .

CELL, 1999, 97 (06) :703-716

[40] EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells [J].

Doetsch, F ;

Petreanu, L ;

Caille, I ;

Garcia-Verdugo, JM ;

Alvarez-Buylla, A .

NEURON, 2002, 36 (06) :1021-1034

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