FoxO transcription factors and stem cell homeostasis: Insights from the hematopoietic system

被引：257

作者：

Tothova, Zuzana ^{[1
]}

Gilliland, D. Gary

机构：

[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[2] Howard Hughes Med Inst, Boston, MA 02115 USA

[3] Harvard MIT, Div Hlth Sci & Technol, Boston, MA 02115 USA

来源：

CELL STEM CELL | 2007年 / 1卷 / 02期

关键词：

D O I：

10.1016/j.stem.2007.07.017

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-dependent signaling is required for long-term regenerative potential of the hematopoietic stem cell (HSC) compartment through regulation of HSC response to physiologic oxidative stress, quiescence, and survival. These observations link FoxO function in mammalian systems with the evolutionarily conserved role of FoxO in promotion of stress resistance and longevity in lower phylogenetic systems. Furthermore, these findings have implications for aging in higher organisms and in malignant stem cell biology, and suggest that FoxOs may play an important role in the maintenance and integrity of stem cell compartments in a broad spectrum of tissues.

引用

页码：140 / 152

页数：13

共 92 条

[51] Mouse development and cell proliferation in the absence of D-cyclins [J].

Kozar, K ;

Ciemerych, MA ;

Rebel, VI ;

Shigematsu, H ;

Zagozdon, A ;

Sicinska, E ;

Geng, Y ;

Yu, QY ;

Bhattacharya, S ;

Bronson, RT ;

Akashi, K ;

Sicinski, P .

CELL, 2004, 118 (04) :477-491

[52] A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span [J].

Lehtinen, Maria K. ;

Yuan, Zengqiang ;

Boag, Peter R. ;

Yang, Yue ;

Villen, Judit ;

Becker, Esther B. E. ;

DiBacco, Sara ;

de la Iglesia, Nuria ;

Gygi, Steven ;

Blackwell, T. Keith ;

Bonni, Azad .

CELL, 2006, 125 (05) :987-1001

[53] Regulation of NF-κB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a [J].

Lin, L ;

Hron, JD ;

Peng, SL .

IMMUNITY, 2004, 21 (02) :203-213

[54] Control of cyclin G2 mRNA expression by forkhead transcription factors:: Novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead [J].

Martínez-Gac, L ;

Marqués, M ;

García, Z ;

Campanero, MR ;

Carrera, AC .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (05) :2181-2189

[55] Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation [J].

Matsuzaki, H ;

Daitoku, H ;

Hatta, M ;

Tanaka, K ;

Fukamizu, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11285-11290

[56] Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation [J].

Matsuzaki, H ;

Daitoku, H ;

Hatta, M ;

Aoyama, H ;

Yoshimochi, K ;

Fukamizu, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (32) :11278-11283

[57] AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 [J].

Medema, RH ;

Kops, GJPL ;

Bos, JL ;

Burgering, BMT .

NATURE, 2000, 404 (6779) :782-787

[58] Foxo3a is essential for maintenance of the hematopoietic stem cell pool [J].

Miyamoto, Kana ;

Araki, Kiyomi Y. ;

Naka, Kazuhito ;

Arai, Fumio ;

Takubo, Keiyo ;

Yamazaki, Satoshi ;

Matsuoka, Sahoko ;

Miyamoto, Takeshi ;

Ito, Keisuke ;

Ohmura, Masako ;

Chen, Chen ;

Hosokawa, Kentaro ;

Nakauchi, Hiromitsu ;

Nakayama, Keiko ;

Nakayama, Keiichi I. ;

Harada, Mine ;

Motoyama, Noboru ;

Suda, Toshio ;

Hirao, Atsushi .

CELL STEM CELL, 2007, 1 (01) :101-112

[59] FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression -: Implications for PTEN mutation in prostate cancer [J].

Modur, V ;

Nagarajan, R ;

Evers, BM ;

Milbrandt, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (49) :47928-47937

[60] The forkhead transcription factor Foxo1 regulates adipocyte differentiation [J].

Nakae, J ;

Kitamura, T ;

Kitamura, Y ;

Biggs, WH ;

Arden, KC ;

Accili, D .

DEVELOPMENTAL CELL, 2003, 4 (01) :119-129

← 1 2 3 4 5 6 7 8 9 10 →