Effects of Selective Anxiolytic Afobazole on Active Caspase-3

被引：11

作者：

Antipova, T. A. ^{[1
]}

Sapozhnikova, D. S.

Stepanichev, M. Yu.

Onufriev, M. V.

Gulyaeva, N. V.

Seredenin, S. B.

机构：

[1] Russian Acad Med Sci, Lab Pharmacol Neuroprotect, VV Zakusov Inst Pharmacol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 02期

关键词：

afobazole; apoptosis; caspase-3; neuroprotection; APOPTOSIS; NECROSIS; ACTIVATION; ISCHEMIA; DEATH;

D O I：

10.1007/s10517-010-0907-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of afobazole on apoptosis through active caspase-3. Afobazole in a final concentration of 10(-8) M inhibits hyperactivation of effector apoptotic caspase-3 in HT-22 cell culture under conditions of glutamate toxicity.

引用

页码：201 / 203

页数：3

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