Antibacterial hydroperoxysterols from Xanthosoma robustum

被引：53

作者：

Kato, T

Frei, B

Heinrich, M

Sticher, O

机构：

[1] ETH ZURICH,DEPT PHARM,CH-8057 ZURICH,SWITZERLAND

[2] INST PHARMACEUT BIOL,D-79104 FREIBURG,GERMANY

来源：

PHYTOCHEMISTRY | 1996年 / 41卷 / 04期

关键词：

Xanthosoma robustum; araceae; hydroperoxides; antibacterial activity; 24-hydroperoxy-4 alpha,14 alpha-dimethylcholesta-8,26-dien-3 beta-ol; 25-hydroperoxy-4 alpha,14 alpha-dimethylcholesta-8,23-dien-3 beta-ol; 25-hydroperoxycycloart-23-en-3; beta-ol; 24-hydroperoxycycloart-25-en-3; 4 alpha,14 alpha-dimethylcholesta-8,24-dien-3 beta-ol; cycloartenol;

D O I：

10.1016/0031-9422(95)00765-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Three new hydroperoxysterols, 24-hydroperoxy-4 alpha,14 alpha-dimethylcholesta-8,25-dien-3 beta-ol, 25-hydroperoxy-4 alpha,14 alpha-dimethylcholesta-8,23-dien-3 beta-ol and 25-hydroperoxycycloart-23-en-3 beta-ol, have been isolated from the aerial parts of Xanthosoma robustum, besides 24-hydroperoxycycloart-25-en-3 beta-ol, 4 alpha, 14 alpha-dimethylcholesta-8,24-dien-3-beta-ol and cycloartenol. Additionally, the two new diols, 4 alpha,14 alpha-dimethylcholesta-8,25-dien-3 beta,24-diol and 4 alpha,14 alpha-dimethylcholesta-8,23-dien-3B,25-diol were obtained from the first two hydroperoxysterols, respectively, by reduction with triphenylphosphine. The structures have been defined by chemical and spectroscopic studies. The four hydroperoxysterols exhibited antibacterial acitivities against Escherichia coli, Bacillus subtilis and micrococcus luteus.

引用

页码：1191 / 1195

页数：5

共 11 条

[1]

OCCURRENCE OF 24-EPIMERS OF CYCLOART-25-ENE-3-BETA,24-DIOLS IN THE STEMS OF EUPHORBIA-TRIGONA [J].