Defined picogram dose inclusion and release of macromolecules using polyelectrolyte microcapsules

被引：62

作者：

Déjugnat, C

Halozan, D

Sukhorukov, GB

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany

[2] Univ Maribor, Maribor 2000, Slovenia

[3] Queen Mary Univ London, IRC Biomed Mat, London E1 4NS, England

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2005年 / 26卷 / 12期

关键词：

encapsulation; layer-by-layer; microreactor; pH sensitivity; stimuli-responsive;

D O I：

10.1002/marc.200500121

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Reversible pH-induced swelling of (PAH/PSS) polyelectrolyte microcapsules is accompanied by increase porosity, making them permeable to poly(acrylic acid)(PAA) at pH values higher than 11.2. This pH-switchable permeability was used to encapsulate the polyanion in alkaline conditions. Relationship between starting PAA concentration in solution and amount finally being encapsulated has been established and can be used further as calibration curve. A desired amount of encapsulate polymer in the picogram range per capsule can be achieved. The loaded capsules were then used as microreactors by forming a complex between the PAA and Ca2+ ions.

引用

页码：961 / 967

页数：7

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