Host-guest binding constants can be estimated directly from the product distributions of dynamic combinatorial libraries

被引：50

作者：

Ludlow, R. Frederick ^{[1
]}

Liu, Jingyuan ^{[1
]}

Li, Hongxia ^{[1
]}

Roberts, Sarah L. ^{[1
]}

Sanders, Jeremy K. M. ^{[1
]}

Otto, Sijbren ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 30期

基金：

英国工程与自然科学研究理事会;

关键词：

combinatorial chemistry; computer chemistry; host-guest systems; supramolecular chemistry;

D O I：

10.1002/anie.200700292

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) Reading a library without opening the books: It is possible to obtain most host-guest binding affinities, even in libraries of more than 30 components, directly from library product distributions by using a numerical data-fitting procedure. With this technique, it is not necessary to isolate any individual library members or measure binding constants. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5762 / 5764

页数：3

共 9 条

[1] Dynamic combinatorial chemistry [J].

Corbett, Peter T. ;

Leclaire, Julien ;

Vial, Laurent ;

West, Kevin R. ;

Wietor, Jean-Luc ;

Sanders, Jeremy K. M. ;

Otto, Sijbren .

CHEMICAL REVIEWS, 2006, 106 (09) :3652-3711

[2] Competition between receptors in dynamic combinatorial libraries: Amplification of the fittest? [J].

Corbett, PT ;

Sanders, JKM ;

Otto, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (26) :9390-9392

[3] Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries [J].

Corbett, PT ;

Otto, S ;

Sanders, JKM .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (13) :3139-3143

[4]

Grote Z., 2003, ANGEW CHEM, V115, P3951

[5]

Jones E., 2001, SciPy: Open source scientific tools for Python

[6] A SIMPLEX-METHOD FOR FUNCTION MINIMIZATION [J].

NELDER, JA ;

MEAD, R .

COMPUTER JOURNAL, 1965, 7 (04) :308-313

[7] Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazones [J].

Roberts, SL ;

Furlan, RLE ;

Otto, S ;

Sanders, JKM .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (09) :1625-1633

[8] Selection experiments with dynamic combinatorial libraries: the importance of the target concentration [J].

Saur, I ;

Severin, K .

CHEMICAL COMMUNICATIONS, 2005, (11) :1471-1473

[9] The advantage of being virtual-target-induced adaptation and selection in dynamic combinatorial libraries [J].

Severin, K .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (10) :2565-2580

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