Selection experiments with dynamic combinatorial libraries: the importance of the target concentration

被引：53

作者：

Saur, I ^{[1
]}

Severin, K ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 11期

关键词：

D O I：

10.1039/b417824f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Experimental data are presented which demonstrate that the target concentration has a strong influence on the outcome of selection experiments with a dynamic mixture of self-assembled receptors.

引用

页码：1471 / 1473

页数：3

共 17 条

[1] A virtual library approach to investigate protein folding and internal packing [J].

Case, MA ;

McLendon, GL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (33) :8089-8090

[2] Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of metal-ion selected dynamic protein libraries [J].

Cooper, HJ ;

Case, MA ;

McLendon, GL ;

Marshall, AG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (18) :5331-5339

[3] Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries [J].

Corbett, PT ;

Otto, S ;

Sanders, JKM .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (13) :3139-3143

[4] PH-Triggered assembly of organometallic receptors for lithium ions [J].

Grote, Z ;

Scopelliti, R ;

Severin, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (51) :16959-16972

[5] Selective complexation of Li+ in water at neutral pH using a self-assembled ionophore [J].

Grote, Z ;

Lehaire, ML ;

Scopelliti, R ;

Severin, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (45) :13638-13639

[6] Adaptive behavior of dynamic combinatorial libraries generated by assembly of different building blocks [J].

Grote, Z ;

Scopelliti, R ;

Severin, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (32) :3821-3825

[7] THERMODYNAMIC AND KINETIC DATA FOR CATION MACROCYCLE INTERACTION [J].

IZATT, RM ;

BRADSHAW, JS ;

NIELSEN, SA ;

LAMB, JD ;

CHRISTENSEN, JJ .

CHEMICAL REVIEWS, 1985, 85 (04) :271-339

[8] Dynamic diversity in drug discovery: Putting small-molecule evolution to work [J].

Karan, C ;

Miller, BL .

DRUG DISCOVERY TODAY, 2000, 5 (02) :67-75

[9]

Lehn JM, 1999, CHEM-EUR J, V5, P2455

[10] Dynamic combinatorial chemistry [J].

Otto, S ;

Furlan, RLE ;

Sanders, JKM .

DRUG DISCOVERY TODAY, 2002, 7 (02) :117-125

← 1 2 →