Total synthesis of (+)-crocacin D

被引：63

作者：

Dias, LC

de Oliveira, LG

Vilcachagua, JD

Nigsch, F

机构：

[1] Univ Estadual Campinas, Inst Quim, Campinas, SP, Brazil

[2] Ecole Normale Super, Dept Chem, F-75231 Paris, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 06期

关键词：

D O I：

10.1021/jo047732k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of (+)-crocacin D is described. The convergent asymmetric synthesis relies on the use of a Stille cross-coupling between an (E)-vinyl stannane with an (E)-vinyl iodide to establish the (E,E)-dienamide moiety followed by a mild and efficient copper-catalyzed coupling between (+)-crocacin C and a (Z)-vinyl iodide to establish the challenging (Z)-enamide function.

引用

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页码：2225 / 2234

页数：10

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