Bacterial zinc uptake and regulators

被引：249

作者：

Hantke, K ^{[1
]}

机构：

[1] Univ Tubingen, D-72076 Tubingen, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 02期

关键词：

D O I：

10.1016/j.mib.2005.02.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Many bacteria use an ABC transporter for high-affinity uptake of zinc with a cluster 9 solute-binding protein. Other members of this protein family transport manganese. At present, it is not always possible to distinguish zinc-specific and manganese-specific transporters on the basis of sequence analysis. Low-affinity ZIP-type zinc transporters in bacteria have also been identified. Most high-affinity zinc uptake systems are regulated by Zur proteins, which form at least three unrelated subgroups of the Fur protein family (regulators of iron transport). High-affinity transport of zinc out of the periplasmic space poses a problem to the cell because zinc is a cofactor of several periplasmic enzymes. Certain zinc-binding proteins in the periplasm might function as chaperones to supply these enzymes with zinc.

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收藏

页码：196 / 202

页数：7

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