Solvent-free biocatalytic amidation of carboxylic acids

被引：38

作者：

Prasad, AK ^{[1
]}

Husain, M

Singh, BK

Gupta, RK

Manchanda, VK

Olsen, CE

Parmar, VS

机构：

[1] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 100007, India

[2] GGSIP Univ, Sch Biotechnol, Delhi 110006, India

[3] Bhabha Atom Res Ctr, Div Radiochem, Bombay 400085, Maharashtra, India

[4] Royal Vet & Agr Univ, Dept Chem, DK-1871 Copenhagen, Denmark

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 26期

关键词：

lipase; enantioselective; amidation; bulk reaction; chiral amide;

D O I：

10.1016/j.tetlet.2005.04.121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lipase-catalyzed enantioselective amidation was performed by reacting the racemic amine with aliphatic acids in nonsolvent system. The reaction equilibrium was shifted towards amide synthesis by the removal of water under reduced pressure. This methodology avoids the use of activating agents and hazardous solvents. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4511 / 4514

页数：4

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