Ischemia-reperfusion and immediate T cell responses

被引：118

作者：

Huang, Yanfei ^{[1
]}

Rabb, Hamid ^{[1
]}

Womer, Karl L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Nephrol, Baltimore, MD 21205 USA

来源：

CELLULAR IMMUNOLOGY | 2007年 / 248卷 / 01期

关键词：

ischemia; T cells; inflammation;

D O I：

10.1016/j.cellimm.2007.03.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pathogenesis of ischemia-reperfusion injury (IRI) is complex and not well understood. Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion molecules, chemokines and cytokines. Emerging data suggest a role of T cells as mediators of IRI both in renal and extra-renal organs. Divergent roles of T cell subsets have also been elucidated, suggesting a more complicated role of T cells in the different phases of IRI This review presents recent evidence from various animal models that advances our understanding of the role T cells play in IRI These findings entertain the possibility of using immunotherapeutic agents for the prevention and treatment of IRI (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：4 / 11

页数：8

共 89 条

[1] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[2] FTY720 pretreatment reduces warm hepatic ischemia reperfusion injury through inhibition of T-lymphocyte infiltration [J].

Anselmo, DM ;

Amersi, FF ;

Shen, XD ;

Gao, F ;

Katori, M ;

Lassman, C ;

Ke, BB ;

Coito, AJ ;

Ma, J ;

Brinkmann, V ;

Busuttil, RW ;

Kupiec-Weglinski, JW ;

Farmer, DG .

AMERICAN JOURNAL OF TRANSPLANTATION, 2002, 2 (09) :843-849

[3] Phenotypic and functional characterization of kidney-infiltrating lymphocytes in renal ischemia reperfusion injury [J].

Ascon, Dolores B. ;

Lopez-Briones, Sergio ;

Liu, Manchang ;

Ascon, Miguel ;

Savransky, Vladimir ;

Colvin, Robert B. ;

Soloski, Mark J. ;

Rabb, Hamid .

JOURNAL OF IMMUNOLOGY, 2006, 177 (05) :3380-3387

[4] Neutrophils do not contribute to infarction, oxidative stress, and NO synthase activity in severe brain ischemia [J].

Beray-Berthat, V ;

Palmier, B ;

Plotkine, M ;

Margaill, I .

EXPERIMENTAL NEUROLOGY, 2003, 182 (02) :446-454

[5] New cellular and molecular immune pathways in ischemia/reperfusion injury [J].

Boros, P ;

Bromberg, JS .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (04) :652-658

[6] Kinetics and localization of interleukin-2, interleukin-6, heat shock protein 70, and interferon gamma during intestinal-rerfusion injury [J].

Braun, F ;

Hosseini, M ;

Wieland, E ;

Sattler, B ;

Müller, AR ;

Fändrich, F ;

Kremer, B ;

Ringe, B .

TRANSPLANTATION PROCEEDINGS, 2004, 36 (02) :267-269

[7] Identification of the CD4+ T cell as a major pathogenic factor in ischemic acute renal failure [J].

Burne, MJ ;

Daniels, F ;

El Ghandour, A ;

Mauiyyedi, S ;

Colvin, RB ;

O'Connell, MP ;

Rabb, H .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (09) :1283-1290

[8] Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: a possible mechanism linking early injury and progressive renal disease? [J].

Burne-Taney, Melissa J. ;

Liu, Manchang ;

Ascon, Dolores ;

Molls, Roshni R. ;

Racusen, Lorraine ;

Rabb, Hamid .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2006, 291 (05) :F981-F986

[9] Decreased capacity of immune cells to cause tissue injury mediates kidney ischemic preconditioning [J].

Burne-Taney, Melissa J. ;

Liu, Manchang ;

Baldwin, William M. ;

Racusen, Lorraine ;

Rabb, Hamid .

JOURNAL OF IMMUNOLOGY, 2006, 176 (11) :7015-7020

[10] Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury [J].

Burne-Taney, MJ ;

Yokota-Ikeda, N ;

Rabb, H .

AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (06) :1186-1193

← 1 2 3 4 5 6 7 8 9 →