Ischemia-reperfusion and immediate T cell responses

被引：118

作者：

Huang, Yanfei ^{[1
]}

Rabb, Hamid ^{[1
]}

Womer, Karl L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Nephrol, Baltimore, MD 21205 USA

来源：

CELLULAR IMMUNOLOGY | 2007年 / 248卷 / 01期

关键词：

ischemia; T cells; inflammation;

D O I：

10.1016/j.cellimm.2007.03.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pathogenesis of ischemia-reperfusion injury (IRI) is complex and not well understood. Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion molecules, chemokines and cytokines. Emerging data suggest a role of T cells as mediators of IRI both in renal and extra-renal organs. Divergent roles of T cell subsets have also been elucidated, suggesting a more complicated role of T cells in the different phases of IRI This review presents recent evidence from various animal models that advances our understanding of the role T cells play in IRI These findings entertain the possibility of using immunotherapeutic agents for the prevention and treatment of IRI (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：4 / 11

页数：8

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