Reaction of an introverted carboxylic acid with carbodiimide

被引：45

作者：

Iwasawa, Tetsuo ^{[1
,2
]}

Wash, Paul ^{[1
,2
]}

Gibson, Christoph ^{[1
,2
]}

Rebek, Julius, Jr. ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON | 2007年 / 63卷 / 28期

关键词：

D O I：

10.1016/j.tet.2007.03.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of carboxylic acids with carbodiimides is reviewed, and an 'introverted' carboxylic acid is proposed as a means of trapping reactive intermediates along the reaction pathway. The introverted acid is a cavitand with the carboxylic function directed toward the floor of the cavity. Its reaction with diisopropyl carbodiimide gives a covalent adduct that is either the elusive O-acylisourea or the commonly encountered N-acylurea. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6506 / 6511

页数：6

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