A synthetic mimic of protein inner space: Buried polar interactions in a deep water-soluble host

被引：56

作者：

Butterfield, Sara M.

Rebek, Julius, Jr.

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 48期

关键词：

D O I：

10.1021/ja0663374

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

A deep water-soluble cavitand was functionalized with a carboxylic acid directed toward the hydrophobic interior of the host. The buried salt-bridge interaction formed with a quinuclidium cationic guest was determined to be worth -3 kcal/mol using a free energy cycle. The strength of the interaction correlates well with buried salt bridges in proteins, indicating that the cavitand interior mimics the hydrophobic inner space of proteins. Copyright © 2006 American Chemical Society.

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页码：15366 / 15367

页数：2

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