Carotenoid action on the immune response

被引:560
作者
Chew, BP [1 ]
Park, JS [1 ]
机构
[1] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA
关键词
antioxidants; carotenoids; immunity;
D O I
10.1093/jn/134.1.257S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Early studies demonstrating the ability of dietary carotenes to prevent infections have left open the possibility that the action of these carotenoids may be through their prior conversion to vitamin A. Subsequent studies to demonstrate the specific action of dietary carotenoids have used carotenoids without provitamin A activity such as lutein, canthaxanthin, lycopene and astaxanthin. In fact, these nonprovitamin A carotenoids were as active, and at times more active, than beta-carotene in enhancing cell-mediated and humoral immune response in animals and humans. Another approach to study the possible specific role of dietary carotenoids has used animals that are inefficient converters of carotenoids to vitamin A, for example the domestic cat. Results have similarly shown immuno-enhancement by nonprovitamin A carotenoids, based either on the relative activity or on the type of immune response affected compared to beta-carotene. Certain carotenoids, acting as antioxidants, can potentially reduce the toxic effects of reactive oxygen species (ROS). These ROS, and therefore carotenoids, have been implicated in the etiology of diseases such as cancer, cardiovascular and neurodegenerative diseases and aging. Recent studies on the role of carotenoids in gene regulation, apoptosis and angiogenesis have advanced our knowledge on the possible mechanism by which carotenoids regulate immune function and cancer.
引用
收藏
页码:257S / 261S
页数:5
相关论文
共 45 条
[41]  
THILSTED JP, 1979, AM J VET RES, V40, P1313
[42]   BOVINE VITAMIN-A AND BETA-CAROTENE INTAKE AND LACTATIONAL STATUS .1. RESPONSIVENESS OF PERIPHERAL-BLOOD POLYMORPHONUCLEAR LEUKOCYTES TO VITAMIN-A AND BETA-CAROTENE CHALLENGE INVITRO [J].
TJOELKER, LW ;
CHEW, BP ;
TANAKA, TS ;
DANIEL, LR .
JOURNAL OF DAIRY SCIENCE, 1988, 71 (11) :3112-3119
[43]  
TOMITA Y, 1987, J NATL CANCER I, V78, P679
[44]  
Verhasselt V, 1999, J IMMUNOL, V162, P2569
[45]   EFFECT OF BETA-CAROTENE ON LYMPHOCYTE SUBPOPULATIONS IN ELDERLY HUMANS - EVIDENCE FOR A DOSE-RESPONSE RELATIONSHIP [J].
WATSON, RR ;
PRABHALA, RH ;
PLEZIA, PM ;
ALBERTS, DS .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 53 (01) :90-94