Use of F-19 NMR spectroscopy to evaluate reactions in solid phase organic synthesis

被引：51

作者：

Svensson, A

Fex, T

Kihlberg, J

机构：

[1] PHARMACIA & UPJOHN,ONCOL IMMUNOL,S-22007 LUND,SWEDEN

[2] LUND UNIV,LUND INST TECHNOL,CTR CHEM & CHEM ENGN,S-22100 LUND,SWEDEN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 42期

关键词：

D O I：

10.1016/0040-4039(96)01704-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Gel-phase F-19 NMR spectroscopy has been used to characterize products from a variety of reactions of fluorinated aromatics linked to a TentaGel resin. High quality spectra were obtained in a few minutes using an ordinary NMR spectrometer, and the F-19 chemical shifts of the support-bound compounds closely matched those of soluble references. In addition, substantial chemical shift differences were obtained for almost all of the synthetic transformations, illustrating the potential of F-19 NMR for rapid monitoring of reactions in solid-phase organic synthesis. Copyright (C) 1996 Elsevier Science Ltd

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页码：7649 / 7652

页数：4

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