Gene regulation in the immune system by long noncoding RNAs

被引：664

作者：

Chen, Y. Grace ^{[1
,2
]}

Satpathy, Ansuman T. ^{[1
,2
,3
]}

Chang, Howard Y. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

来源：

NATURE IMMUNOLOGY | 2017年 / 18卷 / 09期

基金：

美国国家卫生研究院;

关键词：

EDITING ENZYME ADAR1; THEILERS-VIRUS; CIRCULAR RNAS; TRANSCRIPTION FACTOR; CANDIDATE GENE; X-CHROMOSOME; EXPRESSION; REVEALS; CANCER; METHYLATION;

D O I：

10.1038/ni.3771

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation and function of innate and adaptive cell types. In this Review, we focus on mechanisms used by lncRNAs to regulate genes encoding products involved in the immune response, including direct interactions with chromatin, RNA and proteins. In addition, we address new areas of lncRNA biology, such as the functions of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellular processes. We emphasize critical gaps in knowledge and future prospects for the roles of lncRNAs in the immune system and autoimmune disease.

引用

页码：962 / 972

页数：11

共 153 条

[1]

circRNA Biogenesis Competes with Pre-mRNA Splicing [J].

Ashwal-Fluss, Reut ;

Meyer, Markus ;

Pamudurti, Nagarjuna Reddy ;

Ivanov, Andranik ;

Bartok, Osnat ;

Hanan, Mor ;

Evantal, Naveh ;

Memczak, Sebastian ;

Rajewsky, Nikolaus ;

Kadener, Sebastian .

MOLECULAR CELL, 2014, 56 (01) :55-66

[2]

Widespread A-to-I RNA editing of alu-containing mRNAs in the human transcriptome [J].

Athanasiadis, A ;

Rich, A ;

Maas, S .

PLOS BIOLOGY, 2004, 2 (12) :2144-2158

[3]

A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation [J].

Atianand, Maninjay K. ;

Hu, Wenqian ;

Satpathy, Ansuman T. ;

Shen, Ying ;

Ricci, Emiliano P. ;

Alvarez-Dominguez, Juan R. ;

Bhatta, Ankit ;

Schattgen, Stefan A. ;

McGowan, Jason D. ;

Blin, Juliana ;

Braun, Joerg E. ;

Gandhi, Pallavi ;

Moore, Melissa J. ;

Chang, Howard Y. ;

Lodish, Harvey F. ;

Caffrey, Daniel R. ;

Fitzgerald, Katherine A. .

CELL, 2016, 165 (07) :1672-1685

[4]

Bass BL, 1997, RNA, V3, P947

[5]

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells [J].

Batista, Pedro J. ;

Molinie, Benoit ;

Wang, Jinkai ;

Qu, Kun ;

Zhang, Jiajing ;

Li, Lingjie ;

Bouley, Donna M. ;

Lujan, Ernesto ;

Haddad, Bahareh ;

Daneshvar, Kaveh ;

Carter, Ava C. ;

Flynn, Ryan A. ;

Zhou, Chan ;

Lim, Kok-Seong ;

Dedon, Peter ;

Wernig, Marius ;

Mullen, Alan C. ;

Xing, Yi ;

Giallourakis, Cosmas C. ;

Chang, Howard Y. .

CELL STEM CELL, 2014, 15 (06) :707-719

[6]

Bihl F, 1999, GENETICS, V152, P385

[7]

Role of RNA methyltransferases in tissue renewal and pathology [J].

Blanco, Sandra ;

Frye, Michaela .

CURRENT OPINION IN CELL BIOLOGY, 2014, 31 :1-7

[8]

Bokar JA, 1997, RNA, V3, P1233

[9]

BOKAR JA, 1994, J BIOL CHEM, V269, P17697

[10]

Evolutionary comparison provides evidence for pathogenicity of RMRP mutations [J].

Bonafé, L ;

Dermitzakis, ET ;

Unger, S ;

Greenberg, CR ;

Campos-Xavier, BA ;

Zankl, A ;

Ucla, C ;

Antonarakis, SE ;

Superti-Furga, A ;

Reymond, A .

PLOS GENETICS, 2005, 1 (04) :444-454

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