Role of RNA methyltransferases in tissue renewal and pathology

被引：103

作者：

Blanco, Sandra ^{[1
]}

Frye, Michaela ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome Trust, Med Res Council, Cambridge Stem Cell Inst, Cambridge CB2 1QR, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2014年 / 31卷

基金：

欧洲研究理事会; 英国医学研究理事会;

关键词：

RECESSIVE INTELLECTUAL DISABILITY; MESSENGER-RNA; MISU NSUN2; PROTEIN-SYNTHESIS; BINDING PROTEINS; NONCODING RNA; RIBOSOMAL-RNA; METHYLATION; DNMT2; DNA;

D O I：

10.1016/j.ceb.2014.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Over the last five decades more than 100 types of RNA modifications have been identified in organism of all kingdoms of life, yet their function and biological relevance remain largely elusive. The recent development of transcriptome-wide techniques to detect RNA modifications such as N-6-methyladenosine (m(6)A) and 5-methylcytidine (m(5)C) has not only created a new field of research 'the epitranscriptome' but also featured essential regulatory roles of RNA methylation in a wide range of fundamental cellular processes. Here, we discuss the current knowledge of m(6)A and m(5)C RNA methylation pathways and summarize how they impact normal tissues and contribute to human disease.

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页码：1 / 7

页数：7

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