West Nile virus: Recent trends in diagnosis and vaccine development

被引：130

作者：

Dauphin, G. ^{[1
]}

Zientara, S. ^{[1
]}

机构：

[1] AFSSA Alfort, UMR1161 INRA AFSSA ENVA, F-94703 Maisons Alfort, France

来源：

VACCINE | 2007年 / 25卷 / 30期

关键词：

West Nile virus; diagnosis; vaccine;

D O I：

10.1016/j.vaccine.2006.12.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

West Nile virus (WNV) is a mosquito-borne flavivirus, native to Africa, Europe, and Western Asia. In many respects, WNV is an outstanding example of a zoonotic pathogen that has leaped geographical barriers and can cause severe disease in human and horse. Before the emergence of WNV in the USA, only few methods of diagnosis were available. Recently, many changes in the fields of WN diagnosis and prevention have happened. This paper will review all these new tools. After a description of the main concerns in WNV and West Nile (WN) disease in humans and animals, this review will present the main available tests for serology and virology detection, from gold standard tests to more recently developed methods. Finally, licensed vaccines and candidate vaccines developed in humans, horses and birds will also been described. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5563 / 5576

页数：14

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