Novel carboranylporphyrins for application in boron neutron capture therapy (BNCT) of tumors

被引：32

作者：

Clark, JC ^{[1
]}

Fronczek, FR ^{[1
]}

Vicente, MGH ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 14期

基金：

美国国家卫生研究院;

关键词：

BNCT; carborane; pyrrole; porphyrin; carboranylporphyrin;

D O I：

10.1016/j.tetlet.2005.02.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Condensation of a new carboranylpyrrole 1 with benzaldehydes leads to beta-carboranylporphyrins 2 and 3 in good yields. These new porphyrins of high boron content (32-43%) have potential as boron delivery agents for BNCT. The X-ray structures of one beta-carboranylporphyrin, of a carboranylpyrrole, and of a side-product are presented. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2365 / 2368

页数：4

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