Preparation of the new bis(phenanthroline) ligand "Clip-Phen" and evaluation of the nuclease activity of the corresponding copper complex

被引：78

作者：

Pitie, M ^{[1
]}

Donnadieu, B ^{[1
]}

Meunier, B ^{[1
]}

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

来源：

INORGANIC CHEMISTRY | 1998年 / 37卷 / 14期

关键词：

D O I：

10.1021/ic980044x

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The best nuclease activities of 1,10-phenanthroline-copper complexes have been observed for a chelate/metal stoichiometry of 2/1. To favor this stoichiometry, the "Clip-Phen" ligand was synthesized with two 1,10-phenanthroline units linked via their C2-carbons by a short flexible arm. An exogenous amine function was present to allow future vectorization of this new chelating ligand. X-ray analysis of monocrystals of Clip-Phen confirmed its structure. An EPR study of (Clip-Phen)CuCl2 showed that the cupric ion was pentacoordinated with a water molecule as the possible fifth ligand. The Cu(I/II) redox couple was found to be near 85 mV vs SCE, close to the redox couple of (Phen)(2)CuCl2. A comparison of the nuclease activity of copper complexes of Clip-Phen and 1,10-phenanthroline indicated that (Clip-Phen)Cu was the more active.

引用

页码：3486 / 3489

页数：4

共 23 条

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