LIM-homeodomain genes in mammalian development and human disease

被引：105

作者：

Hunter, C

Rhodes, S ^{[1
]}

机构：

[1] Indiana Univ Purdue Univ, Dept Biol, Indianapolis, IN 46202 USA

[2] Indiana Univ Purdue Univ, Indiana Univ Ctr Regenerat Biol & Med, Indianapolis, IN 46202 USA

来源：

MOLECULAR BIOLOGY REPORTS | 2005年 / 32卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

differentiation; mouse; rat; transcription factor;

D O I：

10.1007/s11033-004-7657-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human and mouse genomes each contain at least 12 genes encoding LIM homeodomain ( LIM-HD) transcription factors. These gene regulatory proteins feature two LIM domains in their amino termini and a characteristic DNA binding homeodomain. Studies of mouse models and human patients have established that the LIM-HD factors are critical for the development of specialized cells in multiple tissue types, including the nervous system, skeletal muscle, the heart, the kidneys, and endocrine organs such as the pituitary gland and the pancreas. In this article, we review the roles of the LIM-HD proteins in mammalian development and their involvement in human diseases.

引用

收藏

页码：67 / 77

页数：11

相关论文

共 137 条

[1] Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells [J].

Ahlgren, U ;

Pfaff, SL ;

Jessell, TM ;

Edlund, T ;

Edlund, H .

NATURE, 1997, 385 (6613) :257-260

[2] Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype [J].

Alifragis, P ;

Liapi, A ;

Parnavelas, JG .

JOURNAL OF NEUROSCIENCE, 2004, 24 (24) :5643-5648

[3] Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1 [J].

Ando, K ;

Shioda, S ;

Handa, H ;

Kataoka, K .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2003, 31 (03) :419-425

[4] The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system [J].

Asbreuk, CHJ ;

Van Schaick, HSA ;

Cox, JJ ;

Kromkamp, M ;

Smidt, MP ;

Burbach, JPH .

NEUROSCIENCE, 2002, 109 (02) :287-298

[5] The LIM domain: regulation by association [J].

Bach, I .

MECHANISMS OF DEVELOPMENT, 2000, 91 (1-2) :5-17

[6] P-LIM, A LIM HOMEODOMAIN FACTOR, IS EXPRESSED DURING PITUITARY ORGAN AND CELL COMMITMENT AND SYNERGIZES WITH PIT-1 [J].

BACH, I ;

RHODES, SJ ;

PEARSE, RV ;

HEINZEL, T ;

GLOSS, B ;

SCULLY, KM ;

SAWCHENKO, PE ;

ROSENFELD, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2720-2724

[7] Positional candidate gene analysis of lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes [J].

Barat-Houari, M ;

Clément, K ;

Vatin, V ;

Dina, C ;

Bonhomme, GV ;

Vasseur, F ;

Guy-Grand, B ;

Froguel, P .

DIABETES, 2002, 51 (05) :1640-1643

[8] EMBRYONIC EXPRESSION OF LIM-1, THE MOUSE HOMOLOG OF XENOPUS XLIM-1, SUGGESTS A ROLE IN LATERAL MESODERM DIFFERENTIATION AND NEUROGENESIS [J].

BARNES, JD ;

CROSBY, JL ;

JONES, CM ;

WRIGHT, CVE ;

HOGAN, BLM .

DEVELOPMENTAL BIOLOGY, 1994, 161 (01) :168-178

[9] HYPOCHONDROPLASIA - A REPORT OF 5 KINDREDS [J].

BEALS, RK .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1969, A 51 (04) :728-&

[10] Genetic and physical mapping of the dreher locus on mouse chromosome 1 [J].

Bergstrom, DE ;

Gagnon, LH ;

Eicher, EM .

GENOMICS, 1999, 59 (03) :291-299

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