LIM-homeodomain genes in mammalian development and human disease

被引：105

作者：

Hunter, C

Rhodes, S ^{[1
]}

机构：

[1] Indiana Univ Purdue Univ, Dept Biol, Indianapolis, IN 46202 USA

[2] Indiana Univ Purdue Univ, Indiana Univ Ctr Regenerat Biol & Med, Indianapolis, IN 46202 USA

来源：

MOLECULAR BIOLOGY REPORTS | 2005年 / 32卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

differentiation; mouse; rat; transcription factor;

D O I：

10.1007/s11033-004-7657-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human and mouse genomes each contain at least 12 genes encoding LIM homeodomain ( LIM-HD) transcription factors. These gene regulatory proteins feature two LIM domains in their amino termini and a characteristic DNA binding homeodomain. Studies of mouse models and human patients have established that the LIM-HD factors are critical for the development of specialized cells in multiple tissue types, including the nervous system, skeletal muscle, the heart, the kidneys, and endocrine organs such as the pituitary gland and the pancreas. In this article, we review the roles of the LIM-HD proteins in mammalian development and their involvement in human diseases.

引用

页码：67 / 77

页数：11

共 137 条

[61]

Lavdas AA, 1999, J NEUROSCI, V19, P7881

[62] GSH-4 ENCODES A LIM-TYPE HOMEODOMAIN, IS EXPRESSED IN THE DEVELOPING CENTRAL-NERVOUS-SYSTEM AND IS REQUIRED FOR EARLY POSTNATAL SURVIVAL [J].