Characterization of Metallo-β-Lactamase VIM-27, an A57S Mutant of VIM-1 Associated with Klebsiella pneumoniae ST147

被引：27

作者：

Papagiannitsis, C. C. ^{[2
]}

Kotsakis, S. D. ^{[3
]}

Petinaki, E. ^{[4
]}

Vatopoulos, A. C. ^{[2
]}

Tzelepi, E. ^{[3
]}

Miriagou, V. ^{[3
]}

Tzouvelekis, L. S. ^{[1
,3
]}

机构：

[1] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

[2] Natl Sch Publ Hlth, Dept Microbiol, Athens, Greece

[3] Hellenic Pasteur Inst, Bacteriol Lab, Athens, Greece

[4] Univ Thessalia, Sch Med, Dept Microbiol, Larisa, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 07期

关键词：

PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; CLINICAL ISOLATE; VARIANT; GENE;

D O I：

10.1128/AAC.00238-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

VIM-27 metallo-beta-lactamase, an Ala(57) -> Ser variant of VIM-1, was identified in three Klebsiella pneumoniae isolates belonging to sequence type 147. bla(VIM-27) was part of a class 1 integron carried by non-self-transferable plasmids. Kinetic parameters and MIC determinations indicated that VIM-27 hydrolyzed most beta-lactams, especially imipenem and cefoxitin, less effectively than VIM-1.

引用

页码：3570 / 3572

页数：3

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