An integron-associated β-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum β-lactamase IBC-1

被引：51

作者：

Mavroidi, A

Tzelepi, E

Tsakris, A

Miriagou, V

Sofianou, D

Tzouvelekis, LS

机构：

[1] Natl Univ Athens, Sch Med, Dept Microbiol, Lab Antimicrobial Agents, Athens 115, Greece

[2] Hellenic Pasteur Inst, Bacteriol Lab, Athens, Greece

[3] Aristotle Univ, Sch Med, Dept Microbiol, Thessaloniki, Greece

[4] Hippokrat Gen Hosp, Dept Microbiol, Thessaloniki, Greece

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 48卷 / 05期

关键词：

D O I：

10.1093/jac/48.5.627

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

An extended-spectrum beta -lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. bla(IBC-2) was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these beta -lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-beta -lactams.

引用

页码：627 / 630

页数：4

共 8 条

[1] IBC-1, a novel integron-associated class A β-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain [J].