An expedient method for the synthesis of 6-substituted uracils under microwave irradiation in a solvent-free medium

被引：68

作者：

Devi, I ^{[1
]}

Bhuyan, PJ ^{[1
]}

机构：

[1] Reg Res Lab, Div Med Chem, Jorhat 785006, Assam, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 34期

关键词：

microwave-assisted reactions; 6-hydroxy-uracils; 6-amino-uracils; solvent-free medium;

D O I：

10.1016/j.tetlet.2005.06.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Condensation of malonic acid I and ureas 2a-f proceeds smoothly in the presence of acetic anhydride 3 under microwave irradiation in solvent-free conditions to give 6-hydroxy-uracils 4 in excellent yields. Under identical conditions, the condensation of cyanoacetic acid 5 and ureas 2a,b,g and h in the presence of acetic anhydride 3, followed by cyclization in the presence of sodium hydroxide affords 6-amino-uracils 6 in high yields. The work-up procedures are simple and products need no purification. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5727 / 5729

页数：3

共 32 条

[1]

Concerning alkali and acyl barbituric acids. [J].