The mitochondrial KATP channel-Fact or fiction?

被引：68

作者：

Garlid, Keith D. ^{[1
]}

Halestrap, Andrew P. ^{[2
,3
]}

机构：

[1] Portland State Univ, Dept Biol, Portland, OR 97201 USA

[2] Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England

[3] Univ Bristol, Bristol Heart Inst, Bristol BS8 1TD, Avon, England

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2012年 / 52卷 / 03期

关键词：

MitoK(ATP); Reactive oxygen species; Ischemic preconditioning; Mitochondria; Heart; Potassium channel; SENSITIVE POTASSIUM CHANNELS; PERMEABILITY TRANSITION PORE; MATRIX VOLUME; ISCHEMIA-REPERFUSION; LIGHT-SCATTERING; COMPLEX-II; RAT-HEART; IN-VIVO; DIAZOXIDE; 5-HYDROXYDECANOATE;

D O I：

10.1016/j.yjmcc.2011.12.011

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The mitochondrial ATP-dependent K+ channel (mitoK(ATP)) is widely considered by many to play a central role in cardioprotection by ischemic and pharmacological preconditioning and by ischemic postconditioning. Nevertheless, several laboratories have questioned the existence of mitoK(ATP). This article summarizes the evidence for and against and addresses two key questions: How strong is the evidence for the presence of a K-ATP channel in mitochondria? Are the pharmacological agents used to modulate mitoK(ATP) activity sufficiently specific to allow the role of these channels in cardioprotection to be established? (C) 2011 Elsevier Ltd. All rights reserved.

引用

收藏

页码：578 / 583

页数：6

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