Clastogenic factors in the plasma of children exposed at Chernobyl

被引:54
作者
Emerit, I
Quastel, M
Goldsmith, J
Merkin, L
Levy, A
Cernjavski, L
AlaouiYoussefi, A
Pogossian, A
Riklis, E
机构
[1] CNRS,CTR BIOMED RES,OXYGEN FREE RAD RES GRP,F-75006 PARIS,FRANCE
[2] UNIV PARIS 06,F-75006 PARIS,FRANCE
[3] BEN GURION UNIV NEGEV,SOROKA MED CTR,DEPT NUCL MED,IL-84105 BEER SHEVA,ISRAEL
[4] BEN GURION UNIV NEGEV,DEPT EPIDEMIOL,IL-84105 BEER SHEVA,ISRAEL
关键词
Chernobyl; clastogenic factor;
D O I
10.1016/S0027-5107(96)00187-X
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Clastogenic factors (CFs), as they were described previously in accidentally or therapeutically irradiated persons, in A-bomb survivors and in liquidators of the Chernobyl nuclear power plant, were also detected in the plasma of Chernobyl-exposed children. A high percentage of plasma ultrafiltrates from 170 children, immigrated to Israel in 1990, exerted clastogenic effects in test cultures set up with blood from healthy donors. The differences were highly significant in comparison to children immigrated from 'clean' cities of the former Soviet Union or children born in Israel. The percentage of CF-positive children and the mean values of the adjusted clastogenic scores (ACS) were higher for those coming from Gomel and Mozyr, which are high exposure sites (IAEA measurements), compared to those coming from Kiev. There was no correlation between residual 137-Caesium body burden and presence of CFs. However, both measurements were not done at the same time (in 1990 and 1992-1994, respectively). Also no relationship could be revealed between enlargement of the thyroid gland and CF-positivity. CFs are not only observed after irradiation, but in a variety of chronic inflammatory diseases with autoimmune reactions. They were also described in the congenital breakage syndromes, which are hereditary diseases with the highest cancer incidence in humans. Whether the clastogenic effects continuously produced by circulating CFs represent a risk factor for malignant late effects deserves further study and follow-up. Since CF formation and CF action are mediated by superoxide radicals, prophylactic treatment with antioxidants may be suggested for Chernobyl-exposed children, whose plasma induces a strongly positive CF-test.
引用
收藏
页码:47 / 54
页数:8
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