Class reunion: PTEN joins the nuclear crew

被引：88

作者：

Lian, ZL ^{[1
]}

Di Cristofano, A ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA

来源：

ONCOGENE | 2005年 / 24卷 / 50期

关键词：

PTEN; AKT; nucleus;

D O I：

10.1038/sj.onc.1209089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

引用

页码：7394 / 7400

页数：7

共 89 条

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