Class reunion: PTEN joins the nuclear crew

被引：88

作者：

Lian, ZL ^{[1
]}

Di Cristofano, A ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Human Genet Program, Philadelphia, PA 19111 USA

来源：

ONCOGENE | 2005年 / 24卷 / 50期

关键词：

PTEN; AKT; nucleus;

D O I：

10.1038/sj.onc.1209089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.

引用

页码：7394 / 7400

页数：7

共 89 条

[41] Changes in endometrial PTEN expression throughout the human menstrual cycle [J].

Mutter, GL ;

Lin, MC ;

Fitzgerald, JT ;

Kum, JB ;

Eng, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (06) :2334-+

[42] The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system [J].

Neri, LM ;

Borgatti, P ;

Capitani, S ;

Martelli, AM .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2002, 1584 (2-3) :73-80

[43] Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms [J].

Neri, LM ;

Marchisio, M ;

Colamussi, ML ;

Bertagnolo, V .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 259 (02) :314-320

[44]

NERI LM, 1994, CELL MOL BIOL, V40, P619

[45] Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-ζ translocation to the nucleus of NGF-treated PC12 cells [J].

Neri, LM ;

Martelli, AM ;

Borgatti, P ;

Colamussi, ML ;

Marchisio, M ;

Capitani, S .

FASEB JOURNAL, 1999, 13 (15) :2299-2310

[46] Autocrine signalling through erbB receptors promotes constitutive activation of protein kinase B/Akt in breast cancer cell lines [J].

Nicholson, KM ;

Streuli, CH ;

Anderson, NG .

BREAST CANCER RESEARCH AND TREATMENT, 2003, 81 (02) :117-128

[47] Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein [J].

Okahara, F ;

Ikawa, H ;

Kanaho, Y ;

Maehama, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (44) :45300-45303

[48] Human cancer, PTEN and the PI-3 kinase pathway [J].

Parsons, R .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (02) :171-176

[49]

PEIFFER SL, 1995, CANCER RES, V55, P1922

[50] Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells [J].

Perren, A ;

Komminoth, P ;

Saremaslani, P ;

Matter, C ;

Feurer, S ;

Lees, JA ;

Heitz, PU ;

Eng, C .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (04) :1097-1103

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