Management of idiopathic membranous nephropathy

被引：55

作者：

Ponticelli, Claudio ^{[1
]}

Passerini, Patrizia ^{[2
]}

机构：

[1] Humanitas Hosp, Div Nephrol, I-20089 Milan, Italy

[2] Fdn Osped Maggiore, Div Neprol, Mangiagalli, Regina Elena Mi, Italy

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2010年 / 11卷 / 13期

关键词：

glomerulonephritis; immunosuppressive therapy; membranous nephropathy; nephrotic syndrome; METHYLPREDNISOLONE PLUS CHLORAMBUCIL; NEPHROTIC SYNDROME; LONG-TERM; MYCOPHENOLATE-MOFETIL; CONTROLLED-TRIAL; GLOMERULAR-DISEASE; NATURAL-HISTORY; RISK-FACTORS; CYCLOSPORINE; THERAPY;

D O I：

10.1517/14656566.2010.494599

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Importance of the field: Idiopathic membranous nephropathy (IMN) can have a variable natural course. Treatments able to induce remission can improve the long-term prognosis. However, the optimal therapy for IMN remains controversial. Area covered in this review: We reviewed the historical and current literature from 1979 to 2010 regarding the natural course of IMN and the possible treatments giving special emphasis to randomized controlled trials and to more recent approaches. What the reader will gain: The reader will gain a comprehensive review of the available treatments of IMN. A personal therapeutic algorithm for nephrotic patients with IMN is also provided. Take home message: At least five different treatments showed efficacy in many (but not all) patients with IMN.

引用

页码：2163 / 2175

页数：13

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