Rad54, a Jack of all trades in homologous recombination

被引：118

作者：

Tan, TLR

Kanaar, R

Wyman, C

机构：

[1] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus MC, Dept Radiat Oncol, NL-3000 DR Rotterdam, Netherlands

来源：

DNA REPAIR | 2003年 / 2卷 / 07期

关键词：

Rad54; Rad51; DNA double-strand break repair; chromatin remodeling; nucleosomes;

D O I：

10.1016/S1568-7864(03)00070-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Homologous recombination mediates the transfer or exchange of genetic information between homologous DNA molecules. It plays important roles in central processes in the cell such as genome duplication and DNA damage repair. Recent experiments reveal the surprising versatility of one of its central actors, the Rad54 protein. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：787 / 794

页数：8

相关论文

共 27 条

[11] Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin [J].

Jaskelioff, M ;

Van Komen, S ;

Krebs, JE ;

Sung, P ;

Peterson, CL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :9212-9218

[12] Direct association between the yeast Rad51 and Rad54 recombination proteins [J].

Jiang, H ;

Xie, YQ ;

Houston, P ;

Stemkehale, K ;

Mortensen, UH ;

Rothstein, R ;

Kodadek, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (52) :33181-33186

[13] Rad54 protein exerts diverse modes of ATPase activity on duplex DNA partially and fully covered with Rad51 protein [J].

Kiianitsa, K ;

Solinger, JA ;

Heyer, WD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :46205-46215

[14]

Lim DS, 1996, MOL CELL BIOL, V16, P7133

[15] SUPERCOILING OF THE DNA-TEMPLATE DURING TRANSCRIPTION [J].

LIU, LF ;

WANG, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :7024-7027

[16] Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament [J].

Mazin, AV ;

Bornarth, CJ ;

Solinger, JA ;

Heyer, WD ;

Kowalczykowski, SC .

MOLECULAR CELL, 2000, 6 (03) :583-592

[17]

MAZIN AV, 2003, J BIOL CHEM, V3, P3

[18] Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation [J].

Petukhova, G ;

Van Komen, S ;

Vergano, S ;

Klein, H ;

Sung, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (41) :29453-29462

[19] Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins [J].

Petukhova, G ;

Stratton, S ;

Sung, P .

NATURE, 1998, 393 (6680) :91-94

[20] Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation [J].

Rijkers, T ;

Van den Ouweland, J ;

Morolli, B ;

Rolink, AG ;

Baarends, WM ;

Van Sloun, PPH ;

Lohman, PHM ;

Pastink, A .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6423-6429