Anti-adhesion therapy of bacterial diseases: prospects and problems

被引:315
作者
Ofek, I [1 ]
Hasy, DL
Sharon, N
机构
[1] Tel Aviv Univ, Sackler Sch Med, Dept Human Microbiol, IL-69978 Tel Aviv, Israel
[2] Univ Tennessee, Dept Anat & Neurobiol, Memphis, TN 38163 USA
[3] Vet Adm Med Ctr, Res Serv 151, Memphis, TN 38104 USA
[4] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2003年 / 38卷 / 03期
关键词
cranberry; carbohydrate; fimbria;
D O I
10.1016/S0928-8244(03)00228-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The alarming increase in drug-resistant bacteria makes a search for novel means of fighting bacterial infections imperative. An attractive approach is the use of agents that interfere with the ability of the bacteria to adhere to tissues of the host, since such adhesion is one of the initial stages of the infectious process. The validity of this approach has been unequivocally demonstrated in experiments performed in a wide variety of animals, from mice to monkeys, and recently also in humans. Here we review various approaches to anti-adhesion therapy, including the use of receptor and adhesin analogs, dietary constituents, sublethal concentrations of antibiotics and adhesin-based vaccines. Because anti-adhesive agents are not bactericidal, the propagation and spread of resistant strains is much less likely to occur than as a result of exposure to bactericidal agents, such as antibiotics. Anti-adhesive drugs, once developed, may, therefore, serve as a new means to Fight infectious diseases. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:181 / 191
页数:11
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