Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and electrostatic interactions

被引：23

作者：

Basak, A ^{[1
]}

Bag, SS ^{[1
]}

Bdour, HMM ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 20期

关键词：

D O I：

10.1039/b308976m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel enediynyl amino acids and peptides 3 and 5 - 8 were synthesized and their thermal reactivity towards Bergman cyclization studied and compared with the earlier reported amino acid 4, which demonstrated, for the first time, the effect of H-bonding and electrostatic interactions in lowering the activation energy of Bergman cyclization.

引用

页码：2614 / 2615

页数：2

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