Synthesis of E- and Z-substituted methylene-3,4-dihydro-2H-1-benzopyrans by regio- and stereocontrolled palladium-catalyzed intramolecular cyclization

被引：8

作者：

Barberan, O ^{[1
]}

Alami, M ^{[1
]}

Brion, JD ^{[1
]}

机构：

[1] Fac Pharm, BIOCIS, CNRS, ESA 8076,Lab Chim Therapeut, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 14期

关键词：

carbopalladation; cyclization; iodoalkynes; methylene-3,4-dihydro-2H-1-benzopyrans;

D O I：

10.1016/S0040-4039(01)00241-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereocontrolled synthetic approach to E- and Z-substituted methylene-3.4-dihydro-2H-1-benzopyrans 5 is described from acyclic derivatives using as a key step the palladium-catalyzed intramolecular cyclic carbopalladation of iodoalkynes 4 followed by a carbonylation or a hydride ion capture process. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2657 / 2659

页数：3

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