Neuronal plasticity and functional recovery after ischemic stroke

被引：58

作者：

Cheatwood, Joseph L. ^{[1
,2
,3
]}

Emerick, April J. ^{[1
,3
]}

Kartje, Gwendolyn L. ^{[1
,2
,3
,4
]}

机构：

[1] Hubes VA Hosp, Res Serv, Hines, IL USA

[2] Loyola Univ, Med Ctr, Dept Neurol, Maywood, IL 60153 USA

[3] Loyola Univ, Med Ctr, Inst Neurosci, Maywood, IL 60153 USA

[4] Loyola Univ, Med Ctr, Dept Cellular Biol Neurobiol & Anat, Maywood, IL 60153 USA

来源：

TOPICS IN STROKE REHABILITATION | 2008年 / 15卷 / 01期

关键词：

amphetamine; hemispatial neglect; immunotherapy; movement-based therapies; myelin-associated outgrowth inhibitors; Nogo-A physical therapy; rodents; skilled reaching;

D O I：

10.1310/tsr1501-42

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Ischemic stroke affects many new patients each year. The sequelae of brain ischemia can include lasting sensorimotor and cognitive deficits, which negatively impact quality of life. Currently, treatment options for improving poststroke deficits are limited, and the development of new clinical alternatives to improve functional recovery after stroke is actively under investigation. Anti-Nogo-A immunotherapy to reduce the central nervous system inhibitory environment, cell transplantation strategies, pharmacological agents, and movement-based therapies represent emerging treatments of poststroke deficits through enhancement of neuroanatomical plasticity.

引用

页码：42 / 50

页数：9

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