Neuronal plasticity and functional recovery after ischemic stroke

被引：58

作者：

Cheatwood, Joseph L. ^{[1
,2
,3
]}

Emerick, April J. ^{[1
,3
]}

Kartje, Gwendolyn L. ^{[1
,2
,3
,4
]}

机构：

[1] Hubes VA Hosp, Res Serv, Hines, IL USA

[2] Loyola Univ, Med Ctr, Dept Neurol, Maywood, IL 60153 USA

[3] Loyola Univ, Med Ctr, Inst Neurosci, Maywood, IL 60153 USA

[4] Loyola Univ, Med Ctr, Dept Cellular Biol Neurobiol & Anat, Maywood, IL 60153 USA

来源：

TOPICS IN STROKE REHABILITATION | 2008年 / 15卷 / 01期

关键词：

amphetamine; hemispatial neglect; immunotherapy; movement-based therapies; myelin-associated outgrowth inhibitors; Nogo-A physical therapy; rodents; skilled reaching;

D O I：

10.1310/tsr1501-42

中图分类号：

R49 [康复医学];

学科分类号：

100215 ;

摘要：

Ischemic stroke affects many new patients each year. The sequelae of brain ischemia can include lasting sensorimotor and cognitive deficits, which negatively impact quality of life. Currently, treatment options for improving poststroke deficits are limited, and the development of new clinical alternatives to improve functional recovery after stroke is actively under investigation. Anti-Nogo-A immunotherapy to reduce the central nervous system inhibitory environment, cell transplantation strategies, pharmacological agents, and movement-based therapies represent emerging treatments of poststroke deficits through enhancement of neuroanatomical plasticity.

引用

页码：42 / 50

页数：9

共 76 条

[21] Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration [J].

Fournier, AE ;

GrandPre, T ;

Strittmatter, SM .

NATURE, 2001, 409 (6818) :341-346

[22] Life after cerovive - A personal perspective on ischemic neuroprotection in the post-NXY-059 era [J].

Ginsberg, Myron D. .

STROKE, 2007, 38 (06) :1967-1972

[23] Physiotherapy coupled with dextroamphetamine for rehabilitation after hemiparetic stroke - A randomized, double-blind, placebo-controlled trial [J].

Gladstone, DJ ;

Danells, CJ ;

Armesto, A ;

McIlroy, WE ;

Staines, WR ;

Graham, SJ ;

Herrmann, N ;

Szalai, JP ;

Black, SE .

STROKE, 2006, 37 (01) :179-185

[24] Neglect and related disorders [J].

Heilman, KM ;

Valenstein, E ;

Watson, RT .

SEMINARS IN NEUROLOGY, 2000, 20 (04) :463-470

[25] Neurobiology of unilateral spatial neglect [J].

Hillis, AE .

NEUROSCIENTIST, 2006, 12 (02) :153-163

[26] Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? [J].

Irving, EA ;

Vinson, M ;

Rosin, C ;

Roberts, JC ;

Chapman, DM ;

Facci, L ;

Virley, DJ ;

Skaper, SD ;

Burbidge, SA ;

Walsh, FS ;

Hunter, AJ ;

Parsons, AA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (01) :98-107

[27] Regeneration and plasticity in the brain and spinal cord [J].

Johansson, Barbro B. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (08) :1417-1430

[28]

Kartje GL, 1999, ANN NEUROL, V45, P778, DOI 10.1002/1531-8249(199906)45:6<778::AID-ANA12>3.0.CO

[29]

2-B

[30]

Kelly-Hayes Margaret, 2003, J Stroke Cerebrovasc Dis, V12, P119, DOI 10.1016/S1052-3057(03)00042-9

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