Viral vectors for dendritic cell-based immunotherapy

被引：146

作者：

Jenne, L ^{[1
]}

Schuler, G ^{[1
]}

Steinkasserer, A ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1016/S1471-4906(00)01813-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transduction of dendritic cells (DCs) by viral vectors genetically engineered to express tumor-associated antigens (TAAs) or cytokines can produce a high level of transgene expression and is an attractive approach for DC-based immunotherapy. Ex vivo transduction allows the control of DC quality, antigen quantity and site of DC reinjection. This review evaluates the viral vectors currently being developed for use in DC-based immunotherapy.

引用

页码：102 / 107

页数：6

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