Viral vectors for dendritic cell-based immunotherapy

被引：146

作者：

Jenne, L ^{[1
]}

Schuler, G ^{[1
]}

Steinkasserer, A ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 02期

关键词：

D O I：

10.1016/S1471-4906(00)01813-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transduction of dendritic cells (DCs) by viral vectors genetically engineered to express tumor-associated antigens (TAAs) or cytokines can produce a high level of transgene expression and is an attractive approach for DC-based immunotherapy. Ex vivo transduction allows the control of DC quality, antigen quantity and site of DC reinjection. This review evaluates the viral vectors currently being developed for use in DC-based immunotherapy.

引用

页码：102 / 107

页数：6

共 49 条

[11] CD34(+) hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha .2. Functional analysis [J].

Caux, C ;

Massacrier, C ;

Vanbervliet, B ;

Dubois, B ;

Durand, I ;

Cella, M ;

Lanzavecchia, A ;

Banchereau, J .

BLOOD, 1997, 90 (04) :1458-1470

[12] Maturation, activation, and protection of dendritic cells induced by double-stranded RNA [J].

Cella, M ;

Salio, M ;

Sakakibara, Y ;

Langen, H ;

Julkunen, I ;

Lanzavecchia, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :821-829

[13] Gene therapy with recombinant adenovirus vectors: Evaluation of the host immune response [J].

Christ, M ;

Lusky, M ;

Stoeckel, F ;

Dreyer, D ;

Dieterle, A ;

Michou, AI ;

Pavirani, A ;

Mehtali, M .

IMMUNOLOGY LETTERS, 1997, 57 (1-3) :19-25

[14] High efficiency adenovirus-mediated gene transfer to human dendritic cells [J].

Dietz, AB ;

Vuk-Pavlovic, S .

BLOOD, 1998, 91 (02) :392-398

[15] Vaccinia virus-related events and phenotypic changes after infection of dendritic cells derived from human monocytes [J].

Drillien, R ;

Spehner, D ;

Bohbot, A ;

Hanau, D .

VIROLOGY, 2000, 268 (02) :471-481

[16]

Engelmayer J, 1999, J IMMUNOL, V163, P6762

[17] From sabotage to camouflage: viral evasion of cytotoxic T lymphocyte and natural killer cell-mediated immunity [J].

Farrell, HE ;

Davis-Poynter, NJ .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1998, 9 (03) :369-378

[18]

Grignani F, 1998, CANCER RES, V58, P14

[19] Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro [J].

Gruber, A ;

Kan-Mitchell, J ;

Kuhen, KL ;

Mukai, T ;

Wong-Staal, F .

BLOOD, 2000, 96 (04) :1327-1333

[20] The role of B7 costimulation in T-cell immunity [J].

Harris, NL ;

Ronchese, F .

IMMUNOLOGY AND CELL BIOLOGY, 1999, 77 (04) :304-311

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