Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168:: a novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative

被引：48

作者：

Matsumura, Y

Mori, N

Nakano, T

Sasakura, H

Matsugi, T

Hara, H

Morizawa, Y

机构：

[1] Asahi Glass Co Ltd, Fine Chem Grp, Ichihara 2908566, Japan

[2] Santen Pharmaceut Co Ltd, Ctr Res & Dev, Ikoma 6300101, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 07期

关键词：

D O I：

10.1016/j.tetlet.2003.12.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F-2alpha derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：1527 / 1529

页数：3

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