Regioselective aromatic borylation in an inert solvent

被引：123

作者：

Tse, MK ^{[1
]}

Cho, JY ^{[1
]}

Smith, MR ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 18期

关键词：

D O I：

10.1021/ol0162668

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A protocol for performing Rh catalyzed aromatic borylations in cyclohexane has been devised. Borylation at the 5-position of several 1,3-substituted aromatic species ranging from electron-rich (1,3-(NMe2)(2)C6H4) to electron-deficient (1,3-(CF3)(2)C6H4) yields the corresponding aryl boronate esters. Veratrole was selectively borylated at the 4-position, thus extending regloselectivity to 1,2-substituted benzenes. Selective borylation at the 3-position of an N-protected pyrrole has also been demonstrated, providing a valuable reagent for cross-coupling reactions in a single step.

引用

页码：2831 / 2833

页数：3

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