Increased percentage of IL-12+monocytes in the blood correlates with the presence of active MRI lesions in MS

被引：51

作者：

Makhlouf, K

Weiner, HL

Khoury, SJ

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 119卷 / 01期

关键词：

multiple sclerosis; IL-12; magnetic resonance imaging; disease activity; disability;

D O I：

10.1016/S0165-5728(01)00371-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-12 is a cytokine thought to play a major role in the pathogenesis of multiple sclerosis (MS). We have previously shown that patients with progressive MS have a high percentage of IL-12-producing monocytes in the blood compared to normal individuals. We analyzed 269 blood samples from 189 MS patients for the percentage of IL-12-producing monocytes. We found that the increased IL-12 expression correlates with disability. as measured by the Expanded Disability Status Scale (EDSS), and with disease activity, measured by the presence of gadolinium-enhancing magnetic resonance imaging (MRI) lesions. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：145 / 149

页数：5

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